GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs11603691 | 1 | rs11228973 | chr11:57030244 | PRG2 | chr11:57151267-57191532:- | -0.23 | -3.87 | 0.000116 | Low high density lipoprotein cholesterol levels |
| BRCA | cis | rs11603691 | 1 | rs11229003 | chr11:57108291 | PRG2 | chr11:57151267-57191532:- | -0.18 | -3.38 | 0.000738 | Low high density lipoprotein cholesterol levels |
| BRCA | cis | rs11799420 | 1 | rs112293138 | chr1:171714002 | VAMP4 | chr1:171669298-171711214:- | 0.25 | 7.35 | 3.91E-13 | Hippocampal atrophy |
| BRCA | cis | rs948562 | 1 | rs11229535 | chr11:58348386 | CNTF | chr11:58390146-58393203:+ | 0.17 | 3.65 | 0.000279 | Lymphoma |
| BRCA | cis | rs983392 | 1 | rs11230147 | chr11:59877394 | MS4A4A | chr11:60048139-60076444:+ | -0.11 | -4.42 | 1.09E-5 | Alzheimer's disease (late onset) |
| BRCA | cis | rs983392 | 1 | rs11230155 | chr11:59904959 | MS4A4A | chr11:60048139-60076444:+ | -0.1 | -4.16 | 3.49E-5 | Alzheimer's disease (late onset) |
| BRCA | cis | rs983392 | 1 | rs11230161 | chr11:59920231 | MS4A4A | chr11:60048139-60076444:+ | 0.1 | 4.05 | 5.53E-5 | Alzheimer's disease (late onset) |
| BRCA | cis | rs983392 | 1 | rs11230161 | chr11:59920231 | PRPF19 | chr11:60658021-60674061:- | 0.14 | 3.76 | 0.00018 | Alzheimer's disease (late onset) |
| BRCA | cis | rs12468226 | 1 | rs112306637 | chr2:203198918 | NOP58 | chr2:203130515-203168382:+ | 0.15 | 3.46 | 0.000567 | Urate levels |
| BRCA | cis | rs694739 | 1 | rs11231757 | chr11:64106317 | C11orf20 | chr11:64067863-64072238:+ | 0.13 | 3.4 | 0.000692 | Crohn's disease;Alopecia areata;Psoriasis vulgaris |
| BRCA | cis | rs694739 | 1 | rs11231757 | chr11:64106317 | CCDC88B | chr11:64107695-64125005:+ | -0.09 | -4.51 | 7.07E-6 | Crohn's disease;Alopecia areata;Psoriasis vulgaris |
| BRCA | cis | rs3829251 | 1 | rs11233977 | chr11:71221605 | DHCR7 | chr11:71145459-71159477:- | -0.16 | -3.84 | 0.000132 | Vitamin D levels |
| BRCA | cis | rs11239930 | 1 | rs11239930 | chr1:146560564 | CHD1L | chr1:146714291-146767441:+ | -0.13 | -4.16 | 3.37E-5 | AIDS progression |
| BRCA | cis | rs1116547 | 1 | rs11241206 | chr5:112736692 | YTHDC2 | chr5:112849410-112930979:+ | 0.13 | 3.86 | 0.000118 | Cerebral amyloid angiopathy |
| BRCA | cis | rs1116547 | 1 | rs11241209 | chr5:112768936 | YTHDC2 | chr5:112849410-112930979:+ | 0.14 | 4.13 | 3.86E-5 | Cerebral amyloid angiopathy |